Tablet Manufacturing Method



Manufacturing methods of tablet in details

Tablets are solid dosage forms of medication that are widely used to deliver drugs orally. There are different methods used in the manufacturing of tablets, and here are some of the details on these methods:

(1). Direct Compression:

 This is the most commonly used method for manufacturing tablets, especially for drugs that are stable, have good flow properties, and do not require special processing. In this method, the active ingredient and excipients are mixed together, and the resulting powder blend is compressed into tablets.

(2). Wet Granulation:

 This method is used when the active ingredient or excipients do not have good flow properties, or when the drug requires protection from moisture, heat, or light. In this method, the active ingredient and excipients are mixed with a binder solution, and the resulting wet mass is dried, screened, and compressed into tablets.

(3). Dry Granulation: 

This method is used when the active ingredient is sensitive to moisture or heat and cannot be wet granulated. In this method, the active ingredient and excipients are mixed and compressed into slugs, which are then milled into granules, screened, and compressed into tablets.

(4). Compression Coating: 

This method is used when the active ingredient requires protection from moisture or light. In this method, the active ingredient is compressed into a core tablet, which is then coated with a layer of excipients to form a shell.

(5). Melt Granulation: 

This method is used for drugs that are heat sensitive or have poor solubility. In this method, the active ingredient and excipients are mixed and melted, and the resulting molten mass is cooled, milled, and compressed into tablets.

(6). Hot Melt Extrusion: 

This method is used for drugs that are poorly soluble, poorly compressible, or require controlled release. In this method, the active ingredient and excipients are mixed and extruded under high temperature and pressure, and the resulting extrudate is milled and compressed into tablets.

(7). Freeze Drying: 

This method is used for drugs that are heat or moisture sensitive. In this method, the active ingredient and excipients are frozen and dried under vacuum, and the resulting powder is compressed into tablets.

Overall, the manufacturing method used for tablets depends on the properties of the drug, excipients, and the desired dosage form. Each method has its advantages and disadvantages, and the choice of method depends on the specific requirements of the drug product